1. Age range: healthy people aged 18 and above, 2. Medical history and physical examination were inquired, and the researcher judged that he was in good health, 3. Female subjects of childbearing age were not pregnant (negative urine pregnancy test), were not in lactation and had no family planning in the first 3 months after enrollment, effective contraceptive measures were taken in the first 2 weeks before enrollment, 4. The subjects who are able and willing to complete the whole research plan during the whole follow-up period, 5. The subjects have the ability to understand the research procedure, and voluntarily sign the informed consent after informed consent, and can comply with the requirements of the clinical research protocol.

1. Age range: healthy people aged 18 and above, 2. Medical history and physical examination were inquired, and the researcher judged that he was in good health, 3. Female subjects of childbearing age were not pregnant (negative urine pregnancy test), were not in lactation and had no family planning in the first 3 months after enrollment, effective contraceptive measures were taken in the first 2 weeks before enrollment, 4. The subjects who are able and willing to complete the whole research plan during the whole follow-up period, 5. The subjects have the ability to understand the research procedure, and voluntarily sign the informed consent after informed consent, and can comply with the requirements of the clinical research protocol.

1. Age range: Healthy subjects aged 18 years old and above, 2. By asking for medical history and physical examination, the investigator judged that the health condition is well, 3. Female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrollment. Effective contraceptive measures have been taken within 2 weeks before inclusion, 4. During the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan, 5. With self-ability to understand the research procedures, the informed consent & voluntarily sign an informed consent form and be able to comply with the requirements of the clinical study protocol.

1. Age range: Healthy subjects aged 18 years old and above, 2. By asking for medical history and physical examination, the investigator judged that the health condition is well, 3. Female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrollment. Effective contraceptive measures have been taken within 2 weeks before inclusion, 4. During the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan, 5. With self-ability to understand the research procedures, the informed consent & voluntarily sign an informed consent form and be able to comply with the requirements of the clinical study protocol.