. Hospitalized patients with PCR- documented SARS-CoV-2 RNA from throat /nasopharyngeal swab, samples 2. Aged between 18-80 years old 3. the weight is more than 30kg, and there is no limit for men and women 4. Patients who meet the following conditions: creatinine = 110 umol / L, creatinine clearance rate (EGFR) = 60 ml / min / 1.73m2, 5. AST and ALT = 5 × ULN 6. TBIL = 2 × ULN, 7. Patients who are able to fully understand the purpose, nature, method of the study and the possible reactions to the study drugs, voluntarily participate in the study and sign the informed consent 8. Not having severe acute respiratory syndrome (SARS) 9. Patients not using mechanical ventilation or supplemental oxygen, with peripheral oxygen saturation >94% in room air, and having a respiratory rate below 24 incursions per minute. 6. A Normal ECG Baseline result which remains same throughout the study.

. Hospitalized patients with PCR- documented SARS-CoV-2 RNA from throat /nasopharyngeal swab, samples 2. Aged between 18-80 years old 3. the weight is more than 30kg, and there is no limit for men and women 4. Patients who meet the following conditions: creatinine = 110 umol / L, creatinine clearance rate (EGFR) = 60 ml / min / 1.73m2, 5. AST and ALT = 5 × ULN 6. TBIL = 2 × ULN, 7. Patients who are able to fully understand the purpose, nature, method of the study and the possible reactions to the study drugs, voluntarily participate in the study and sign the informed consent 8. Not having severe acute respiratory syndrome (SARS) 9. Patients not using mechanical ventilation or supplemental oxygen, with peripheral oxygen saturation >94% in room air, and having a respiratory rate below 24 incursions per minute. 6. A Normal ECG Baseline result which remains same throughout the study.