patients with liver dysfunction (AST and/or ALT > 5 times of reference values)patients with renal dysfunction (serum creatinine > 2.0 mg/dl)patients with severe ECG abnormalities and/or cardiac diseasespatients with malignancy or history of malignancypatients who are expected to transfer to other hospital within 72 hourspregnant or lactating women

patients with liver dysfunction (AST and/or ALT > 5 times of reference values)patients with renal dysfunction (serum creatinine > 2.0 mg/dl)patients with severe ECG abnormalities and/or cardiac diseasespatients with malignancy or history of malignancypatients who are expected to transfer to other hospital within 72 hourspregnant or lactating women