Patients must satisfy all of the following criteria to be included in the <br/ >study: <br/ >1. Males or females of age 18 to 65 years of Indian origin and diagnosed with COVID-19 by reverse transcription polymerase chain <br/ >reaction (RT-PCR) assay. <br/ >2. Informed consent by the patient or his/her legal representative in case the patient is not capable of giving the consent. <br/ >3. Patients diagnosed with COVID-19 pneumonia causing moderate and severe ARDS as per the Berlin ARDS definition. <br/ >a. Respiratory failure within one week of a known insult or new and/or worsening respiratory symptoms <br/ >b. Respiratory failure not fully explained by cardiac function or volume overload <br/ >c. Moderate to severe hypoxemia must be present, defined as the <br/ >ratio of PaO2/FiO2 on at least PEEP 5cmH2O: <br/ >i Moderate ARDS: PaO2/FiO2 >100 mmHg and ?200 mmHg, on <br/ >ventilator settings that include PEEP ?5 cm H2O OR <br/ >ii Severe ARDS: PaO2/FiO2 ?100 mmHg on ventilator settings that include PEEP ?5 cm H2O <br/ >d. Bilateral opacities in chest X-ray or CT scan. <br/ >4. Patients requiring mechanical ventilatory support. <br/ >5. Patients who can start receiving BMMSCs within 72 hours (3 days) after the diagnosis of ARDS.

Patients must satisfy all of the following criteria to be included in the <br/ >study: <br/ >1. Males or females of age 18 to 65 years of Indian origin and diagnosed with COVID-19 by reverse transcription polymerase chain <br/ >reaction (RT-PCR) assay. <br/ >2. Informed consent by the patient or his/her legal representative in case the patient is not capable of giving the consent. <br/ >3. Patients diagnosed with COVID-19 pneumonia causing moderate and severe ARDS as per the Berlin ARDS definition. <br/ >a. Respiratory failure within one week of a known insult or new and/or worsening respiratory symptoms <br/ >b. Respiratory failure not fully explained by cardiac function or volume overload <br/ >c. Moderate to severe hypoxemia must be present, defined as the <br/ >ratio of PaO2/FiO2 on at least PEEP 5cmH2O: <br/ >i Moderate ARDS: PaO2/FiO2 >100 mmHg and ?200 mmHg, on <br/ >ventilator settings that include PEEP ?5 cm H2O OR <br/ >ii Severe ARDS: PaO2/FiO2 ?100 mmHg on ventilator settings that include PEEP ?5 cm H2O <br/ >d. Bilateral opacities in chest X-ray or CT scan. <br/ >4. Patients requiring mechanical ventilatory support. <br/ >5. Patients who can start receiving BMMSCs within 72 hours (3 days) after the diagnosis of ARDS.

Patients must satisfy all of the following criteria to be included in the <br/ >study: <br/ >1. Males or females of age 18 to 65 years of Indian origin and diagnosed with COVID-19 by reverse transcription polymerase chain <br/ >reaction (RT-PCR) assay. <br/ >2. Informed consent by the patient or his/her legal representative in case the patient is not capable of giving the consent. <br/ >3. Patients diagnosed with COVID-19 pneumonia causing moderate and severe ARDS as per the Berlin ARDS definition. <br/ >a. Respiratory failure within one week of a known insult or new and/or worsening respiratory symptoms <br/ >b. Respiratory failure not fully explained by cardiac function or volume overload <br/ >c. Moderate to severe hypoxemia must be present, defined as the <br/ >ratio of PaO2/FiO2 on at least PEEP 5cmH2O: <br/ >i Moderate ARDS: PaO2/FiO2 >100 mmHg and ?200 mmHg, on <br/ >ventilator settings that include PEEP ?5 cm H2O OR <br/ >ii Severe ARDS: PaO2/FiO2 ?100 mmHg on ventilator settings that include PEEP ?5 cm H2O <br/ >d. Bilateral opacities in chest X-ray or CT scan. <br/ >4. Patients requiring mechanical ventilatory support. <br/ >5. Patients who can start receiving BMMSCs within 72 hours (3 days) after the diagnosis of ARDS.

Patients must satisfy all of the following criteria to be included in the <br/ >study: <br/ >1. Males or females of age 18 to 65 years of Indian origin and diagnosed with COVID-19 by reverse transcription polymerase chain <br/ >reaction (RT-PCR) assay. <br/ >2. Informed consent by the patient or his/her legal representative in case the patient is not capable of giving the consent. <br/ >3. Patients diagnosed with COVID-19 pneumonia causing moderate and severe ARDS as per the Berlin ARDS definition. <br/ >a. Respiratory failure within one week of a known insult or new and/or worsening respiratory symptoms <br/ >b. Respiratory failure not fully explained by cardiac function or volume overload <br/ >c. Moderate to severe hypoxemia must be present, defined as the <br/ >ratio of PaO2/FiO2 on at least PEEP 5cmH2O: <br/ >i Moderate ARDS: PaO2/FiO2 >100 mmHg and ?200 mmHg, on <br/ >ventilator settings that include PEEP ?5 cm H2O OR <br/ >ii Severe ARDS: PaO2/FiO2 ?100 mmHg on ventilator settings that include PEEP ?5 cm H2O <br/ >d. Bilateral opacities in chest X-ray or CT scan. <br/ >4. Patients requiring mechanical ventilatory support. <br/ >5. Patients who can start receiving BMMSCs within 72 hours (3 days) after the diagnosis of ARDS.