1. Male or female subjects aged >=18 years old at the recruitment, 2. The subject can provide with informed consent and signs and dates a written informed consent form (ICF) prior to the initiation of any trial procedures, 3. They must be able to understand and follow trial-related instructions. They must be willing and able to comply with planned visits, treatment schedule, laboratory tests and other requirements of the trial, 4. Negative in HIV antibody test, 5. Axillary temperature <=37.0 degrees C, 6. Negative finding in nucleic acid screening of SARS-CoV-2, 7. Negative in antibodies (IgG and IgM) test of SARS-CoV-2, 8. Negative finding in chest CT examine for COVID-19, 9. Body mass index (BMI) 18.5 to 30, 10. There were no significant abnormalities in blood routine, blood biochemistry, coagulation function and urine routine, or no clinical significance was determined by doctors (including white blood cell count, lymphocyte count, neutrophil count, platelet, hemoglobin, glutamic pyruvic transaminase ALT, glutamic oxaloacetic transaminase AST, total bilirubin, fasting blood glucose, creatinine, prothrombin time, partially activated prothrombin time, urine protein, urine red blood cells), 11. Healthy subjects who have been examined by medical history, physical examination and clinical examination are in accordance with the immunization of this vaccine.

1. Male or female subjects aged >=18 years old at the recruitment, 2. The subject can provide with informed consent and signs and dates a written informed consent form (ICF) prior to the initiation of any trial procedures, 3. They must be able to understand and follow trial-related instructions. They must be willing and able to comply with planned visits, treatment schedule, laboratory tests and other requirements of the trial, 4. Negative in HIV antibody test, 5. Axillary temperature <=37.0 degrees C, 6. Negative finding in nucleic acid screening of SARS-CoV-2, 7. Negative in antibodies (IgG and IgM) test of SARS-CoV-2, 8. Negative finding in chest CT examine for COVID-19, 9. Body mass index (BMI) 18.5 to 30, 10. There were no significant abnormalities in blood routine, blood biochemistry, coagulation function and urine routine, or no clinical significance was determined by doctors (including white blood cell count, lymphocyte count, neutrophil count, platelet, hemoglobin, glutamic pyruvic transaminase ALT, glutamic oxaloacetic transaminase AST, total bilirubin, fasting blood glucose, creatinine, prothrombin time, partially activated prothrombin time, urine protein, urine red blood cells), 11. Healthy subjects who have been examined by medical history, physical examination and clinical examination are in accordance with the immunization of this vaccine.