* known hypersensitivity to hydroxychloroquine manifested as anaphylaxis * current treatment to chloroquine or hydroxychloroquine * women with last menstruation date farther than a month without negative pregnancy test. * women with positive pregnancy test * breastfeeding women * chronic hepatic disease history (child-pugh b or c) * chronic renal disease (gfr less or equal to 30)

* known hypersensitivity to hydroxychloroquine manifested as anaphylaxis * current treatment to chloroquine or hydroxychloroquine * women with last menstruation date farther than a month without negative pregnancy test. * women with positive pregnancy test * breastfeeding women * chronic hepatic disease history (child-pugh b or c) * chronic renal disease (gfr less or equal to 30)

- known hypersensitivity to hydroxychloroquine manifested as anaphylaxis - current treatment to chloroquine or hydroxychloroquine - women with last menstruation date farther than a month without negative pregnancy test. - women with positive pregnancy test - breastfeeding women - chronic hepatic disease history (child-pugh b or c) - chronic renal disease (gfr less or equal to 30)

- known hypersensitivity to hydroxychloroquine manifested as anaphylaxis - current treatment to chloroquine or hydroxychloroquine - women with last menstruation date farther than a month without negative pregnancy test. - women with positive pregnancy test - breastfeeding women - chronic hepatic disease history (child-pugh b or c) - chronic renal disease (gfr less or equal to 30)