Presence of any of the following: Need to supplement oxygen more than 4L, Use of high flow nasal catheter, Use of non-invasive ventilation, Use of mechanical ventilation, Use of hidroxichoroquine, chloroquine, azithromycin or other macrolide over 24 hours, History of severe ventricular or QTC equal or grater than 48 ms cardiac arrithmia, History of hepatic desease (cirrosis), Renal dysfunction (estimated glomerular filtration rate [eGFR] less than 30ml/min/1.73m2, using MDRD or CKD-EPI method), Patients with retinopathy or macular degeneration, Children under 18 years,Pregnancy, Allergy to chloroquine and derivatives, Allergy to azythromicyn, Patients in hospital over 48hr, Patients with symptoms over 14 days

Presence of any of the following: Need to supplement oxygen more than 4L, Use of high flow nasal catheter, Use of non-invasive ventilation, Use of mechanical ventilation, Use of hidroxichoroquine, chloroquine, azithromycin or other macrolide over 24 hours, History of severe ventricular or QTC equal or grater than 48 ms cardiac arrithmia, History of hepatic desease (cirrosis), Renal dysfunction (estimated glomerular filtration rate [eGFR] less than 30ml/min/1.73m2, using MDRD or CKD-EPI method), Patients with retinopathy or macular degeneration, Children under 18 years,Pregnancy, Allergy to chloroquine and derivatives, Allergy to azythromicyn, Patients in hospital over 48hr, Patients with symptoms over 14 days