It is not possible to take drugs orally or through a gastroenteric feeding tube, With significantly abnormal liver function (Child Pugh C), Previous renal failure: patients who previously underwent dialysis, or patients with GFR less than or equal to 30 mL / min / 1.73 m2, NYHA (New York Heart Association) heart failure 3 or 4, COPD GOLD 3 and 4, Neoplasia, Autoimmune disease, Individuals with known hypersensitivity to study drugs, People who have already been treated with the study drug during the last 30 days, Clinical or radiological suspicion of tuberculosis and bacterial pneumonia.

It is not possible to take drugs orally or through a gastroenteric feeding tube, With significantly abnormal liver function (Child Pugh C), Previous renal failure: patients who previously underwent dialysis, or patients with GFR less than or equal to 30 mL / min / 1.73 m2, NYHA (New York Heart Association) heart failure 3 or 4, COPD GOLD 3 and 4, Neoplasia, Autoimmune disease, Individuals with known hypersensitivity to study drugs, People who have already been treated with the study drug during the last 30 days, Clinical or radiological suspicion of tuberculosis and bacterial pneumonia.