G6PD enzyme deficiency (activity below 60% according to Yoshida classification 242, Pregnancy, Women in lactation Clinically decompensated hyperthyroidism, Severe decompensated arterial hypertension, Severe active or recent bleeding from severe Anemia (Hemoglobin less than 6 g / dL), severe unstable cardiovascular disease , Participation in another clinical study for less than 30 days, Impossibility of adhering to the research protocol, Any important clinical condition that, in the Investigator's opinion, may bring risks to the patient and prevent him from proceeding safely, Suspected or recent pregnancy as a precaution due to ethical issues, since there are studies of genotoxicity in experimental animals proving the safety of Ozone Therapy in the sense of the absence of genetic changes induced by Medicinal Ozone, any important clinical condition that in the Researcher's opinion may bring risks to the patient and prevent that the research protocol proceeds with safety

G6PD enzyme deficiency (activity below 60% according to Yoshida classification 242, Pregnancy, Women in lactation Clinically decompensated hyperthyroidism, Severe decompensated arterial hypertension, Severe active or recent bleeding from severe Anemia (Hemoglobin less than 6 g / dL), severe unstable cardiovascular disease , Participation in another clinical study for less than 30 days, Impossibility of adhering to the research protocol, Any important clinical condition that, in the Investigator's opinion, may bring risks to the patient and prevent him from proceeding safely, Suspected or recent pregnancy as a precaution due to ethical issues, since there are studies of genotoxicity in experimental animals proving the safety of Ozone Therapy in the sense of the absence of genetic changes induced by Medicinal Ozone, any important clinical condition that in the Researcher's opinion may bring risks to the patient and prevent that the research protocol proceeds with safety