Participants with any of the following characteristics will be excluded: Individuals who have had a fever in the last 15 days, pregnant or lactating women, individuals with suspected viral infection including COVID-19 or bacterial in the past 15 days before randomization, have had a previous diagnosis of tuberculosis, has had a vaccination in the last 15 days, immunocompromised or with neutrophil count below 500 / mm3, using corticosteroids, antibiotics and chemotherapy drugs, present or have presented a solid or non-solid tumor in the last 2 years, or who are directly involved in the project.

Participants with any of the following characteristics will be excluded: Individuals who have had a fever in the last 15 days, pregnant or lactating women, individuals with suspected viral infection including COVID-19 or bacterial in the past 15 days before randomization, have had a previous diagnosis of tuberculosis, has had a vaccination in the last 15 days, immunocompromised or with neutrophil count below 500 / mm3, using corticosteroids, antibiotics and chemotherapy drugs, present or have presented a solid or non-solid tumor in the last 2 years, or who are directly involved in the project.

Participants with any of the following characteristics will be excluded: Individuals who have had a fever in the last 15 days, pregnant or lactating women, individuals with suspected viral infection including COVID-19 or bacterial in the past 15 days, have had a previous diagnosis of tuberculosis, has had a vaccination in the last 15 days, immunocompromised or with neutrophil count below 500 / mm3, using corticosteroids, antibiotics and chemotherapy drugs, present or have presented a solid or non-solid tumor in the last 2 years, or who are directly involved in the project or are positive for COVID-19 on day 15 after randomization.

Participants with any of the following characteristics will be excluded: Individuals who have had a fever in the last 15 days, pregnant or lactating women, individuals with suspected viral infection including COVID-19 or bacterial in the past 15 days, have had a previous diagnosis of tuberculosis, has had a vaccination in the last 15 days, immunocompromised or with neutrophil count below 500 / mm3, using corticosteroids, antibiotics and chemotherapy drugs, present or have presented a solid or non-solid tumor in the last 2 years, or who are directly involved in the project or are positive for COVID-19 on day 15 after randomization.

Any participant with a known reaction to BCG vaccine, or those with latent TB, individuals who have had a fever in the past 24 hours, pregnant women, individuals with suspected viral or bacterial infection, have had a vaccination in the last 4 weeks (influenza for example), immunocompromised or with neutrophil count below 500 / mm3, transplanted, using corticosteroids in the last month, present or have presented a solid or non-solid tumor in the last 2 years, or who are directly involved in the project or are positive for COVID-19

Any participant with a known reaction to BCG vaccine, or those with latent TB, individuals who have had a fever in the past 24 hours, pregnant women, individuals with suspected viral or bacterial infection, have had a vaccination in the last 4 weeks (influenza for example), immunocompromised or with neutrophil count below 500 / mm3, transplanted, using corticosteroids in the last month, present or have presented a solid or non-solid tumor in the last 2 years, or who are directly involved in the project or are positive for COVID-19