Men or women, 18 years of age or older Ability to provide informed consent signed by study patient or legally acceptable representative Requires ICU hospitalization. Respiratory sign or symptom (cough, difficulty breathing, sputum production, nasal or conjunctival congestion, difficulty swallowing, sore throat, runny nose Need for oxygen support using a nasal catheter up to 6 l / min to keep SaO2 above 94% or SpO2 <94% in room air. Bilateral infiltrate at Rx or signs suggestive of COVID-19 pneumonia on chest tomography, Less than seven days after the first flu-like symptom.

Men or women, 18 years of age or older Ability to provide informed consent signed by study patient or legally acceptable representative Requires ICU hospitalization. Respiratory sign or symptom (cough, difficulty breathing, sputum production, nasal or conjunctival congestion, difficulty swallowing, sore throat, runny nose Need for oxygen support using a nasal catheter up to 6 l / min to keep SaO2 above 94% or SpO2 <94% in room air. Bilateral infiltrate at Rx or signs suggestive of COVID-19 pneumonia on chest tomography, Less than seven days after the first flu-like symptom.