Need for oxygen support in a nasal catheter over 6 l / min to maintain SaO2 above 93% or signs of respiratory distress for more than 6 h, Patient intubated and on mechanical ventilatory support, Need for vasopressor or signs of shock, Chronic renal failure or AKI Kdigo I or greater, History of bleeding or recent peptic ulcer 6 months, Suspected infections suggestive of fungal or bacterial etiologies, Chronic hepatitis C infection in antiviral therapy, Severely immunocompromised in the investigator's opinion (eg, differentiation cluster count 4+ [CD4 +] less than 200 cells / mm3, absolute neutrophil count less than 750 / mm3, first chemotherapy cycle completed in the 2 weeks prior to screening, history of stem cell transplantation within the period of 1 year prior to screening, any history of solid organ transplantation, Pregnant women, Patients with a life expectancy of less than 30 days

Need for oxygen support in a nasal catheter over 6 l / min to maintain SaO2 above 93% or signs of respiratory distress for more than 6 h, Patient intubated and on mechanical ventilatory support, Need for vasopressor or signs of shock, Chronic renal failure or AKI Kdigo I or greater, History of bleeding or recent peptic ulcer 6 months, Suspected infections suggestive of fungal or bacterial etiologies, Chronic hepatitis C infection in antiviral therapy, Severely immunocompromised in the investigator's opinion (eg, differentiation cluster count 4+ [CD4 +] less than 200 cells / mm3, absolute neutrophil count less than 750 / mm3, first chemotherapy cycle completed in the 2 weeks prior to screening, history of stem cell transplantation within the period of 1 year prior to screening, any history of solid organ transplantation, Pregnant women, Patients with a life expectancy of less than 30 days