1) Age &#8805,18 years and &#8804,79 years 2) Have positive SARS-CoV-2 result 3) Be hospitalized due to diagnosis of pneumonia (chest X-ray or computerized tomography [CT] scan) 4) Be developing new onset of oxygenation impairment requiring any of the following: high-flow oxygen (&#8805,15L/min), non-invasive ventilation (e.g. CPAP, iPAP), mechanical ventilation &#8804,48h prior to dose 5) Have increased biological markers of systemic inflammation. 6) No gender restriction 7) Female participants must meet and agree to abide by the contraceptive criteria. 8) Capable of giving written informed consent. If participants are not capable of giving written informed consent, alternative consent procedures. For more details check the protocol

1) Age &#8805,18 years and &#8804,79 years 2) Have positive SARS-CoV-2 result 3) Be hospitalized due to diagnosis of pneumonia (chest X-ray or computerized tomography [CT] scan) 4) Be developing new onset of oxygenation impairment requiring any of the following: high-flow oxygen (&#8805,15L/min), non-invasive ventilation (e.g. CPAP, iPAP), mechanical ventilation &#8804,48h prior to dose 5) Have increased biological markers of systemic inflammation. 6) No gender restriction 7) Female participants must meet and agree to abide by the contraceptive criteria. 8) Capable of giving written informed consent. If participants are not capable of giving written informed consent, alternative consent procedures. For more details check the protocol