&#1048576, 18 years old or older &#1048576, Hospitalized patient with COVID-19 disease, confirmed by a molecular test or a serologic test, along with a typical COVID-19 clinical presentation. &#1048576, Severe or critical disease caused by COVID-19 Severe disease is defined as 2 or more of the following criteria: • Respiratory frequency >22 • O2 saturation &#8804,93% • PaO2 <60mmHg, PaCO2 >50mmHg o • PaO2/FiO2 <300 Or Critical disease with one or more o the following criteria: • Respiratory insufficiency with requirement of mechanical ventilation within the last 72hours • Shock &#1048576, Inform consent signed by patient or direct family member

&#1048576, 18 years old or older &#1048576, Hospitalized patient with COVID-19 disease, confirmed by a molecular test or a serologic test, along with a typical COVID-19 clinical presentation. &#1048576, Severe or critical disease caused by COVID-19 Severe disease is defined as 2 or more of the following criteria: • Respiratory frequency >22 • O2 saturation &#8804,93% • PaO2 <60mmHg, PaCO2 >50mmHg o • PaO2/FiO2 <300 Or Critical disease with one or more o the following criteria: • Respiratory insufficiency with requirement of mechanical ventilation within the last 72hours • Shock &#1048576, Inform consent signed by patient or direct family member