1. Hospitalized patients &#8805,18 años 2. Informed consent 3. Confirmed diagnosis of SARS-CoV2 infection via RT-PCR of nasopharingeal swabing 4. Patients at risk of progression defined as having two or more of the following: • Ferritin > 500 ng/mL • D-dimer > 1 mg/L • Reactive C-Protein > 15 mg/L • Total Lymphocytes < 1000/mm3 or Neutrophil/Lymphocyte ratio > 3.13 • Admission to a Intense care unit for management of COVID-19 or pacients with severe diasease defined as having two or more of the following: • Dispnea • Respiratory rate >= 30 per minute • Oxygen Saturation < 93% • Po2/Fio2 < 300 • Lung infiltrates > 50% in chest X-ray or Chest CT scan Iwith increasing compromise in a 24-48 hours period

1. Hospitalized patients &#8805,18 años 2. Informed consent 3. Confirmed diagnosis of SARS-CoV2 infection via RT-PCR of nasopharingeal swabing 4. Patients at risk of progression defined as having two or more of the following: • Ferritin > 500 ng/mL • D-dimer > 1 mg/L • Reactive C-Protein > 15 mg/L • Total Lymphocytes < 1000/mm3 or Neutrophil/Lymphocyte ratio > 3.13 • Admission to a Intense care unit for management of COVID-19 or pacients with severe diasease defined as having two or more of the following: • Dispnea • Respiratory rate >= 30 per minute • Oxygen Saturation < 93% • Po2/Fio2 < 300 • Lung infiltrates > 50% in chest X-ray or Chest CT scan Iwith increasing compromise in a 24-48 hours period