2 Exclusion criteria for donors of CP a) Patients aged less than 18 years of age (18 years is the legal consent age in Kenya) b) Symptomatic patients with COVID-19 c) Patients with fever of unknown origin d) Patients who don’t meet Kenyan standards of blood donation e.g anemic patients, underweight (less than 50kg), chronic diseases such as HIV, hepatitis B and C, cancers, uncontrolled hypertension etc. e) Females who have given birth or had an abortion due to high risk of TRALI f) Patients who decline or are unable to give informed consent to donate CP. Exclusion Criteria for recipients of CP: • History of allergic reaction to blood or blood products • Participation in other clinical trials. • Religious reasons such as Jehovah witnesses’ practitioners who decline blood/blood products. • Refusal to give informed consent by the patient or next of kin • Known IgA deficiency • Medical conditions in which receipt of 350mL volume may be detrimental to the patient (e.g., decompensated congestive heart failure, renal failure) • Females who are pregnant or breast feeding

2 Exclusion criteria for donors of CP a) Patients aged less than 18 years of age (18 years is the legal consent age in Kenya) b) Symptomatic patients with COVID-19 c) Patients with fever of unknown origin d) Patients who don’t meet Kenyan standards of blood donation e.g anemic patients, underweight (less than 50kg), chronic diseases such as HIV, hepatitis B and C, cancers, uncontrolled hypertension etc. e) Females who have given birth or had an abortion due to high risk of TRALI f) Patients who decline or are unable to give informed consent to donate CP. Exclusion Criteria for recipients of CP: • History of allergic reaction to blood or blood products • Participation in other clinical trials. • Religious reasons such as Jehovah witnesses’ practitioners who decline blood/blood products. • Refusal to give informed consent by the patient or next of kin • Known IgA deficiency • Medical conditions in which receipt of 350mL volume may be detrimental to the patient (e.g., decompensated congestive heart failure, renal failure) • Females who are pregnant or breast feeding