1. ALT/AST > 5 times the upper limit of normal. 2. Stage 4 severe chronic kidney disease or requiring dialysis (i.e. eGFR < 30) 3. Pregnant or breast feeding. 4. Anticipated transfer to another hospital which is not a study site within 72 hours. 5. Patients with hematological diseases. 6.Patients with chronic liver and kidney disease and reaching end-stage. 7. Patients with arrhythmia and chronic heart disease. 8. Patients known to have retinal disease, hearing loss or hearing loss. 9. Patients known to have a mental illness. 10. Skin disorders (including rash, dermatitis, psoriasis). 11. Allergy to any study medication (4-aminoquinoline).

1. ALT/AST > 5 times the upper limit of normal. 2. Stage 4 severe chronic kidney disease or requiring dialysis (i.e. eGFR < 30) 3. Pregnant or breast feeding. 4. Anticipated transfer to another hospital which is not a study site within 72 hours. 5. Patients with hematological diseases. 6.Patients with chronic liver and kidney disease and reaching end-stage. 7. Patients with arrhythmia and chronic heart disease. 8. Patients known to have retinal disease, hearing loss or hearing loss. 9. Patients known to have a mental illness. 10. Skin disorders (including rash, dermatitis, psoriasis). 11. Allergy to any study medication (4-aminoquinoline).