Pharmacokinetic endpoints- Hydroxychloroquine plasma concentration- Hydroxychloroquine whole blood concentration Pharmacodynamic endpoints- Endosomal TLR responseso TLR3-driven cytokine production o TLR7-driven cytokine productiono TLR8-driven cytokine productiono TLR9-driven cytokine production- T cell responseso Proliferation o Activation marker expressiono Cytokine production - B cell responseso Activation marker expressiono Proliferation- Leukocyte differentiation - Flow cytometry phenotyping of dendritic cells; monocytes; T cells and B cells

Pharmacokinetic endpoints- Hydroxychloroquine plasma concentration- Hydroxychloroquine whole blood concentration Pharmacodynamic endpoints- Endosomal TLR responseso TLR3-driven cytokine production o TLR7-driven cytokine productiono TLR8-driven cytokine productiono TLR9-driven cytokine production- T cell responseso Proliferation o Activation marker expressiono Cytokine production - B cell responseso Activation marker expressiono Proliferation- Leukocyte differentiation - Flow cytometry phenotyping of dendritic cells; monocytes; T cells and B cells