inclusion criteria: * diagnosed with coronavirus disease 2019 (covid-19) and confirmed severe acute respiratory syndrome coronavirus 2 (sars-cov-2) viral infection * severe or critical covid-19, or national institute of allergy and infectious diseases (niaid) 8-point ordinal score 2, 3 or 4 (scale 2: requiring invasive mechanical ventilation or extracorporeal membrane oxygenation (ecmo); scale 3: non-invasive ventilation or high flow oxygen devices; scale 4: supplemental oxygen support; a peripheral capillary oxygen saturation (spo2) \</= 94% or tachypnea (respiratory rate \>/= 24 breaths/min). intubation should be within 7 days

inclusion criteria: * diagnosed with coronavirus disease 2019 (covid-19) and confirmed severe acute respiratory syndrome coronavirus 2 (sars-cov-2) viral infection * severe or critical covid-19, or national institute of allergy and infectious diseases (niaid) 8-point ordinal score 2, 3 or 4 (scale 2: requiring invasive mechanical ventilation or extracorporeal membrane oxygenation (ecmo); scale 3: non-invasive ventilation or high flow oxygen devices; scale 4: supplemental oxygen support; a peripheral capillary oxygen saturation (spo2) \</= 94% or tachypnea (respiratory rate \>/= 24 breaths/min). intubation should be within 7 days

inclusion criteria: - diagnosed with coronavirus disease 2019 (covid-19) and confirmed severe acute respiratory syndrome coronavirus 2 (sars-cov-2) viral infection - severe or critical covid-19, or national institute of allergy and infectious diseases (niaid) 8-point ordinal score 2, 3 or 4 (scale 2: requiring invasive mechanical ventilation or extracorporeal membrane oxygenation (ecmo); scale 3: non-invasive ventilation or high flow oxygen devices; scale 4: supplemental oxygen support; a peripheral capillary oxygen saturation (spo2) </= 94% or tachypnea (respiratory rate >/= 24 breaths/min). intubation should be within 7 days

inclusion criteria: - diagnosed with coronavirus disease 2019 (covid-19) and confirmed severe acute respiratory syndrome coronavirus 2 (sars-cov-2) viral infection - severe or critical covid-19, or national institute of allergy and infectious diseases (niaid) 8-point ordinal score 2, 3 or 4 (scale 2: requiring invasive mechanical ventilation or extracorporeal membrane oxygenation (ecmo); scale 3: non-invasive ventilation or high flow oxygen devices; scale 4: supplemental oxygen support; a peripheral capillary oxygen saturation (spo2) </= 94% or tachypnea (respiratory rate >/= 24 breaths/min). intubation should be within 7 days

inclusion criteria: 1. should be at least 18 years of age, 2. male or female, 3. diagnosed with covid-19 and confirmed sars-cov-2 viral infection. 4. able to sign the consent form by subject or by legal authorized representative. 5. severe or critical covid-19, or niaid 8-point ordinal score 2, 3 or 4 (scale 2: requiring invasive mechanical ventilation or ecmo; scale 3: non-invasive ventilation or high flow oxygen devices; scale 4: supplemental oxygen support; a peripheral capillary oxygen saturation (spo2) </= 94% or tachypnea (respiratory rate >/= 24 breaths/min). intubation should be within 7 days.

inclusion criteria: 1. should be at least 18 years of age, 2. male or female, 3. diagnosed with covid-19 and confirmed sars-cov-2 viral infection. 4. able to sign the consent form by subject or by legal authorized representative. 5. severe or critical covid-19, or niaid 8-point ordinal score 2, 3 or 4 (scale 2: requiring invasive mechanical ventilation or ecmo; scale 3: non-invasive ventilation or high flow oxygen devices; scale 4: supplemental oxygen support; a peripheral capillary oxygen saturation (spo2) </= 94% or tachypnea (respiratory rate >/= 24 breaths/min). intubation should be within 7 days.

inclusion criteria: 1. should be at least 18 years of age, 2. male or female, 3. diagnosed with covid-19 and confirmed sars-cov-2 viral infection. 4. able to sign the consent form by subject or by legal authorized representative. 5. severe or critical covid-19, or niaid 8-point ordinal score 2, 3 or 4 (scale 2: requiring requiring invasive mechanical ventilation or ecmo; scale 3: non-invasive ventilation or high flow oxygen devices; scale 4: supplemental oxygen support; a spo2 </= 94% or tachypnea (respiratory rate >/= 24 breaths/min). intubation should be within 7 days.

inclusion criteria: 1. should be at least 18 years of age, 2. male or female, 3. diagnosed with covid-19 and confirmed sars-cov-2 viral infection. 4. able to sign the consent form by subject or by legal authorized representative. 5. severe or critical covid-19, or niaid 8-point ordinal score 2, 3 or 4 (scale 2: requiring requiring invasive mechanical ventilation or ecmo; scale 3: non-invasive ventilation or high flow oxygen devices; scale 4: supplemental oxygen support; a spo2 </= 94% or tachypnea (respiratory rate >/= 24 breaths/min). intubation should be within 7 days.