1. individuals with any positive test for sars-cov-2 infection, including but not limited to rt-pcr, at screening (excluding the sars-cov-2 seropositive treatment group \[treatment groups 16 to 18\]). 2. individuals with positive serology test results for sars-cov-2 at screening (excluding the sars-cov-2 seropositive treatment group \[treatment groups 16 to 18\]). 3. individuals with behavioral or cognitive impairment in the opinion of the investigator. 4. individuals with any progressive or severe neurologic disorder, seizure disorder, or history of guillian-barré syndrome. 5. individuals who are not able to comprehend and to follow all required study procedures for the whole period of the study. 6. individuals with known or suspected impairment of the immune system, such as: 1. use of systemic (oral or parenteral) corticosteroids for ≥14 consecutive days within 60 days prior to day 1. use of inhaled, intranasal, or topical corticosteroids is allowed.note: systemic (oral or parenteral) corticosteroids are also prohibited for 3 weeks after the second dose of the study vaccine/placebo. 2. receipt of cancer chemotherapy within 5 years prior to day 1. 3. receipt of immunostimulants or immunosuppressants within 60 days prior to day 1. 4. known hiv or acquired immune deficiency syndrome (aids). 5. subjects with active or prior documented autoimmune disorder (such as potential immune-mediated diseases \[pimds\]). 6. receipt of parenteral immunoglobulin preparation, blood products, and/or plasma derivatives within 3 months prior to day 1 or planned during the full length of the study. 7. positive serology test results for hepatitis c virus antibody, hiv antibody, and/or hepatitis b virus surface antigen at screening. 8. individuals who are pregnant or breastfeeding. 9. individuals who are allergic to any of the study vaccine/placebo components as outlined in the current scb 2019 ib. 10. individuals who have had a malignancy (excluding nonmelanotic skin cancer) or lymphoproliferative disorder within the past 5 years from the date of first administration of the study vaccine/placebo (day 1). 11. individuals who have received any other investigational product within 30 days prior to day 1 or intent to participate in another clinical study at any time during the conduct of this study. 12. individuals with a body temperature ≥38.0 °c (≥100.4 °f) or any acute illness within 3 days of intended study vaccination. 13. individuals who have a previous confirmed or suspected illness caused by coronaviruses, sars-cov-1, sars-cov-2, and middle east respiratory syndrome (mers)-cov (excluding the sars-cov-2 seropositive treatment group \[treatment groups 16 to 18\]). 14. individuals who have received any prior vaccine against a coronavirus, including but not limited to sars-cov, sars-cov-2, mers-cov. 15. individuals who have received any other licensed vaccines within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to enrollment in this study or who are planning to receive any vaccine within 28 days (before or after) the study vaccine/placebos, with the exception of the seasonal influenza vaccine. 16. presence of uncontrolled chronic pulmonary, cardiovascular, renal, hepatic, neurologic, hematologic or metabolic (including diabetes mellitus) disorders, which would include the potential subject in a high-risk category for sars cov 2 infection and/or its complications. 17. individuals with known bleeding diathesis. 18. individuals with a body mass index \<18.5 kg/m2 or \>35.0 kg/m2. 19. individuals with a history of drug or alcohol abuse within the past 2 years. 20. individuals with a history of anaphylaxis or angioedema including but not limited to history of anaphylaxis after any vaccine. 21. individuals with any condition that, in the opinion of the investigator, would interfere with the primary study objectives or pose additional subject risk. 22. individuals who are research staff involved with the clinical study or family/household members of research staff. 23. individuals must not have donated blood for 2 months prior to day 1 and must agree to not donate blood for 6 months post day 1 (receipt of first dose of study vaccine).

1. individuals with any positive test for sars-cov-2 infection, including but not limited to rt-pcr, at screening (excluding the sars-cov-2 seropositive treatment group \[treatment groups 16 to 18\]). 2. individuals with positive serology test results for sars-cov-2 at screening (excluding the sars-cov-2 seropositive treatment group \[treatment groups 16 to 18\]). 3. individuals with behavioral or cognitive impairment in the opinion of the investigator. 4. individuals with any progressive or severe neurologic disorder, seizure disorder, or history of guillian-barré syndrome. 5. individuals who are not able to comprehend and to follow all required study procedures for the whole period of the study. 6. individuals with known or suspected impairment of the immune system, such as: 1. use of systemic (oral or parenteral) corticosteroids for ≥14 consecutive days within 60 days prior to day 1. use of inhaled, intranasal, or topical corticosteroids is allowed.note: systemic (oral or parenteral) corticosteroids are also prohibited for 3 weeks after the second dose of the study vaccine/placebo. 2. receipt of cancer chemotherapy within 5 years prior to day 1. 3. receipt of immunostimulants or immunosuppressants within 60 days prior to day 1. 4. known hiv or acquired immune deficiency syndrome (aids). 5. subjects with active or prior documented autoimmune disorder (such as potential immune-mediated diseases \[pimds\]). 6. receipt of parenteral immunoglobulin preparation, blood products, and/or plasma derivatives within 3 months prior to day 1 or planned during the full length of the study. 7. positive serology test results for hepatitis c virus antibody, hiv antibody, and/or hepatitis b virus surface antigen at screening. 8. individuals who are pregnant or breastfeeding. 9. individuals who are allergic to any of the study vaccine/placebo components as outlined in the current scb 2019 ib. 10. individuals who have had a malignancy (excluding nonmelanotic skin cancer) or lymphoproliferative disorder within the past 5 years from the date of first administration of the study vaccine/placebo (day 1). 11. individuals who have received any other investigational product within 30 days prior to day 1 or intent to participate in another clinical study at any time during the conduct of this study. 12. individuals with a body temperature ≥38.0 °c (≥100.4 °f) or any acute illness within 3 days of intended study vaccination. 13. individuals who have a previous confirmed or suspected illness caused by coronaviruses, sars-cov-1, sars-cov-2, and middle east respiratory syndrome (mers)-cov (excluding the sars-cov-2 seropositive treatment group \[treatment groups 16 to 18\]). 14. individuals who have received any prior vaccine against a coronavirus, including but not limited to sars-cov, sars-cov-2, mers-cov. 15. individuals who have received any other licensed vaccines within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to enrollment in this study or who are planning to receive any vaccine within 28 days (before or after) the study vaccine/placebos, with the exception of the seasonal influenza vaccine. 16. presence of uncontrolled chronic pulmonary, cardiovascular, renal, hepatic, neurologic, hematologic or metabolic (including diabetes mellitus) disorders, which would include the potential subject in a high-risk category for sars cov 2 infection and/or its complications. 17. individuals with known bleeding diathesis. 18. individuals with a body mass index \<18.5 kg/m2 or \>35.0 kg/m2. 19. individuals with a history of drug or alcohol abuse within the past 2 years. 20. individuals with a history of anaphylaxis or angioedema including but not limited to history of anaphylaxis after any vaccine. 21. individuals with any condition that, in the opinion of the investigator, would interfere with the primary study objectives or pose additional subject risk. 22. individuals who are research staff involved with the clinical study or family/household members of research staff. 23. individuals must not have donated blood for 2 months prior to day 1 and must agree to not donate blood for 6 months post day 1 (receipt of first dose of study vaccine).

individuals with any positive test for sars-cov-2 infection, including but not limited to rt-pcr, at screening (excluding the sars-cov-2 seropositive treatment group [treatment groups 16 to 18]). individuals with positive serology test results for sars-cov-2 at screening (excluding the sars-cov-2 seropositive treatment group [treatment groups 16 to 18]). individuals with behavioral or cognitive impairment in the opinion of the investigator. individuals with any progressive or severe neurologic disorder, seizure disorder, or history of guillian-barré syndrome. individuals who are not able to comprehend and to follow all required study procedures for the whole period of the study. individuals with known or suspected impairment of the immune system, such as: use of systemic (oral or parenteral) corticosteroids for ≥14 consecutive days within 60 days prior to day 1. use of inhaled, intranasal, or topical corticosteroids is allowed.note: systemic (oral or parenteral) corticosteroids are also prohibited for 3 weeks after the second dose of the study vaccine/placebo. receipt of cancer chemotherapy within 5 years prior to day 1. receipt of immunostimulants or immunosuppressants within 60 days prior to day 1. known hiv or acquired immune deficiency syndrome (aids). subjects with active or prior documented autoimmune disorder (such as potential immune-mediated diseases [pimds]). receipt of parenteral immunoglobulin preparation, blood products, and/or plasma derivatives within 3 months prior to day 1 or planned during the full length of the study. positive serology test results for hepatitis c virus antibody, hiv antibody, and/or hepatitis b virus surface antigen at screening. individuals who are pregnant or breastfeeding. individuals who are allergic to any of the study vaccine/placebo components as outlined in the current scb 2019 ib. individuals who have had a malignancy (excluding nonmelanotic skin cancer) or lymphoproliferative disorder within the past 5 years from the date of first administration of the study vaccine/placebo (day 1). individuals who have received any other investigational product within 30 days prior to day 1 or intent to participate in another clinical study at any time during the conduct of this study. individuals with a body temperature ≥38.0 °c (≥100.4 °f) or any acute illness within 3 days of intended study vaccination. individuals who have a previous confirmed or suspected illness caused by coronaviruses, sars-cov-1, sars-cov-2, and middle east respiratory syndrome (mers)-cov (excluding the sars-cov-2 seropositive treatment group [treatment groups 16 to 18]). individuals who have received any prior vaccine against a coronavirus, including but not limited to sars-cov, sars-cov-2, mers-cov. individuals who have received any other licensed vaccines within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to enrollment in this study or who are planning to receive any vaccine within 28 days (before or after) the study vaccine/placebos, with the exception of the seasonal influenza vaccine. presence of uncontrolled chronic pulmonary, cardiovascular, renal, hepatic, neurologic, hematologic or metabolic (including diabetes mellitus) disorders, which would include the potential subject in a high-risk category for sars cov 2 infection and/or its complications. individuals with known bleeding diathesis. individuals with a body mass index <18.5 kg/m2 or >35.0 kg/m2. individuals with a history of drug or alcohol abuse within the past 2 years. individuals with a history of anaphylaxis or angioedema including but not limited to history of anaphylaxis after any vaccine. individuals with any condition that, in the opinion of the investigator, would interfere with the primary study objectives or pose additional subject risk. individuals who are research staff involved with the clinical study or family/household members of research staff. individuals must not have donated blood for 2 months prior to day 1 and must agree to not donate blood for 6 months post day 1 (receipt of first dose of study vaccine).

individuals with any positive test for sars-cov-2 infection, including but not limited to rt-pcr, at screening (excluding the sars-cov-2 seropositive treatment group [treatment groups 16 to 18]). individuals with positive serology test results for sars-cov-2 at screening (excluding the sars-cov-2 seropositive treatment group [treatment groups 16 to 18]). individuals with behavioral or cognitive impairment in the opinion of the investigator. individuals with any progressive or severe neurologic disorder, seizure disorder, or history of guillian-barré syndrome. individuals who are not able to comprehend and to follow all required study procedures for the whole period of the study. individuals with known or suspected impairment of the immune system, such as: use of systemic (oral or parenteral) corticosteroids for ≥14 consecutive days within 60 days prior to day 1. use of inhaled, intranasal, or topical corticosteroids is allowed.note: systemic (oral or parenteral) corticosteroids are also prohibited for 3 weeks after the second dose of the study vaccine/placebo. receipt of cancer chemotherapy within 5 years prior to day 1. receipt of immunostimulants or immunosuppressants within 60 days prior to day 1. known hiv or acquired immune deficiency syndrome (aids). subjects with active or prior documented autoimmune disorder (such as potential immune-mediated diseases [pimds]). receipt of parenteral immunoglobulin preparation, blood products, and/or plasma derivatives within 3 months prior to day 1 or planned during the full length of the study. positive serology test results for hepatitis c virus antibody, hiv antibody, and/or hepatitis b virus surface antigen at screening. individuals who are pregnant or breastfeeding. individuals who are allergic to any of the study vaccine/placebo components as outlined in the current scb 2019 ib. individuals who have had a malignancy (excluding nonmelanotic skin cancer) or lymphoproliferative disorder within the past 5 years from the date of first administration of the study vaccine/placebo (day 1). individuals who have received any other investigational product within 30 days prior to day 1 or intent to participate in another clinical study at any time during the conduct of this study. individuals with a body temperature ≥38.0 °c (≥100.4 °f) or any acute illness within 3 days of intended study vaccination. individuals who have a previous confirmed or suspected illness caused by coronaviruses, sars-cov-1, sars-cov-2, and middle east respiratory syndrome (mers)-cov (excluding the sars-cov-2 seropositive treatment group [treatment groups 16 to 18]). individuals who have received any prior vaccine against a coronavirus, including but not limited to sars-cov, sars-cov-2, mers-cov. individuals who have received any other licensed vaccines within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to enrollment in this study or who are planning to receive any vaccine within 28 days (before or after) the study vaccine/placebos, with the exception of the seasonal influenza vaccine. presence of uncontrolled chronic pulmonary, cardiovascular, renal, hepatic, neurologic, hematologic or metabolic (including diabetes mellitus) disorders, which would include the potential subject in a high-risk category for sars cov 2 infection and/or its complications. individuals with known bleeding diathesis. individuals with a body mass index <18.5 kg/m2 or >35.0 kg/m2. individuals with a history of drug or alcohol abuse within the past 2 years. individuals with a history of anaphylaxis or angioedema including but not limited to history of anaphylaxis after any vaccine. individuals with any condition that, in the opinion of the investigator, would interfere with the primary study objectives or pose additional subject risk. individuals who are research staff involved with the clinical study or family/household members of research staff. individuals must not have donated blood for 2 months prior to day 1 and must agree to not donate blood for 6 months post day 1 (receipt of first dose of study vaccine).

individuals with any positive test for sars cov 2 infection, including but not limited to rt-pcr, at screening. individuals with positive serology test results for sars cov 2 at screening. individuals with behavioral or cognitive impairment in the opinion of the investigator. individuals with any progressive or severe neurologic disorder, seizure disorder, or history of guillian-barré syndrome. individuals who are not able to comprehend and to follow all required study procedures for the whole period of the study. individuals with known or suspected impairment of the immune system, such as: use of systemic (oral or parenteral) corticosteroids for ≥14 consecutive days within 60 days prior to day 1. use of inhaled, intranasal, or topical corticosteroids is allowed.note: systemic (oral or parenteral) corticosteroids are also prohibited for 3 weeks after the second dose of the study vaccine/placebo. receipt of cancer chemotherapy within 5 years prior to day 1. receipt of immunostimulants or immunosuppressants within 60 days prior to day 1. known hiv or acquired immune deficiency syndrome (aids). subjects with active or prior documented autoimmune disorder (such as potential immune-mediated diseases [pimds]). receipt of parenteral immunoglobulin preparation, blood products, and/or plasma derivatives within 3 months prior to day 1 or planned during the full length of the study. positive serology test results for hepatitis c virus antibody, hiv antibody, and/or hepatitis b virus surface antigen at screening. individuals who are pregnant or breastfeeding. female subjects of childbearing potential must have a negative pregnancy test prior to administration of the study vaccine/placebo. individuals who are allergic to any of the study vaccine/placebo components as outlined in the current scb 2019 ib. individuals who have had a malignancy (excluding nonmelanotic skin cancer) or lymphoproliferative disorder within the past 5 years from the date of first administration of the study vaccine/placebo (day 1). individuals who have received any other investigational product within 30 days prior to day 1 or intent to participate in another clinical study at any time during the conduct of this study. individuals with a body temperature ≥38.0 °c (≥100.4 °f) or any acute illness within 3 days of intended study vaccination. individuals who have a previous confirmed or suspected illness caused by coronaviruses, sars-cov 1, sars-cov-2, and middle east respiratory syndrome (mers)-cov. individuals who have received any prior vaccine against a coronavirus, including but not limited to sars-cov, sars-cov-2, mers-cov. individuals who have received any other licensed vaccines within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to enrollment in this study or who are planning to receive any vaccine within 28 days (before or after) the study vaccine/placebos, with the exception of the seasonal influenza vaccine. presence of uncontrolled chronic pulmonary, cardiovascular, renal, hepatic, neurologic, hematologic or metabolic (including diabetes mellitus) disorders, which would include the potential subject in a high-risk category for sars cov 2 infection and/or its complications. individuals with known bleeding diathesis. individuals with a body mass index <18.5 kg/m2 or >35.0 kg/m2. individuals with a history of drug or alcohol abuse within the past 2 years. individuals with a history of anaphylaxis or angioedema including but not limited to history of anaphylaxis after any vaccine. individuals with any condition that, in the opinion of the investigator, would interfere with the primary study objectives or pose additional subject risk. individuals who are research staff involved with the clinical study or family/household members of research staff.

individuals with any positive test for sars cov 2 infection, including but not limited to rt-pcr, at screening. individuals with positive serology test results for sars cov 2 at screening. individuals with behavioral or cognitive impairment in the opinion of the investigator. individuals with any progressive or severe neurologic disorder, seizure disorder, or history of guillian-barré syndrome. individuals who are not able to comprehend and to follow all required study procedures for the whole period of the study. individuals with known or suspected impairment of the immune system, such as: use of systemic (oral or parenteral) corticosteroids for ≥14 consecutive days within 60 days prior to day 1. use of inhaled, intranasal, or topical corticosteroids is allowed.note: systemic (oral or parenteral) corticosteroids are also prohibited for 3 weeks after the second dose of the study vaccine/placebo. receipt of cancer chemotherapy within 5 years prior to day 1. receipt of immunostimulants or immunosuppressants within 60 days prior to day 1. known hiv or acquired immune deficiency syndrome (aids). subjects with active or prior documented autoimmune disorder (such as potential immune-mediated diseases [pimds]). receipt of parenteral immunoglobulin preparation, blood products, and/or plasma derivatives within 3 months prior to day 1 or planned during the full length of the study. positive serology test results for hepatitis c virus antibody, hiv antibody, and/or hepatitis b virus surface antigen at screening. individuals who are pregnant or breastfeeding. female subjects of childbearing potential must have a negative pregnancy test prior to administration of the study vaccine/placebo. individuals who are allergic to any of the study vaccine/placebo components as outlined in the current scb 2019 ib. individuals who have had a malignancy (excluding nonmelanotic skin cancer) or lymphoproliferative disorder within the past 5 years from the date of first administration of the study vaccine/placebo (day 1). individuals who have received any other investigational product within 30 days prior to day 1 or intent to participate in another clinical study at any time during the conduct of this study. individuals with a body temperature ≥38.0 °c (≥100.4 °f) or any acute illness within 3 days of intended study vaccination. individuals who have a previous confirmed or suspected illness caused by coronaviruses, sars-cov 1, sars-cov-2, and middle east respiratory syndrome (mers)-cov. individuals who have received any prior vaccine against a coronavirus, including but not limited to sars-cov, sars-cov-2, mers-cov. individuals who have received any other licensed vaccines within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to enrollment in this study or who are planning to receive any vaccine within 28 days (before or after) the study vaccine/placebos, with the exception of the seasonal influenza vaccine. presence of uncontrolled chronic pulmonary, cardiovascular, renal, hepatic, neurologic, hematologic or metabolic (including diabetes mellitus) disorders, which would include the potential subject in a high-risk category for sars cov 2 infection and/or its complications. individuals with known bleeding diathesis. individuals with a body mass index <18.5 kg/m2 or >35.0 kg/m2. individuals with a history of drug or alcohol abuse within the past 2 years. individuals with a history of anaphylaxis or angioedema including but not limited to history of anaphylaxis after any vaccine. individuals with any condition that, in the opinion of the investigator, would interfere with the primary study objectives or pose additional subject risk. individuals who are research staff involved with the clinical study or family/household members of research staff.

1. individuals with any positive test for sars cov 2 infection, including but not limited to rt-pcr, at screening. 2. individuals with positive serology test results for sars cov 2 at screening. 3. individuals with behavioral or cognitive impairment in the opinion of the investigator. 4. individuals with any progressive or severe neurologic disorder, seizure disorder, or history of guillian-barré syndrome. 5. individuals who are not able to comprehend and to follow all required study procedures for the whole period of the study. 6. individuals with known or suspected impairment of the immune system, such as: 1. use of systemic (oral or parenteral) corticosteroids for ≥14 consecutive days within 60 days prior to day 1. use of inhaled, intranasal, or topical corticosteroids is allowed.note: systemic (oral or parenteral) corticosteroids are also prohibited for 3 weeks after the second dose of the study vaccine/placebo. 2. receipt of cancer chemotherapy within 5 years prior to day 1. 3. receipt of immunostimulants or immunosuppressants within 60 days prior to day 1. 4. known hiv or acquired immune deficiency syndrome (aids). 5. subjects with active or prior documented autoimmune disorder (such as potential immune-mediated diseases [pimds]). 6. receipt of parenteral immunoglobulin preparation, blood products, and/or plasma derivatives within 3 months prior to day 1 or planned during the full length of the study. 7. positive serology test results for hepatitis c virus antibody, hiv antibody, and/or hepatitis b virus surface antigen at screening. 8. individuals who are pregnant or breastfeeding. female subjects of childbearing potential must have a negative pregnancy test prior to administration of the study vaccine/placebo. 9. individuals who are allergic to any of the study vaccine/placebo components as outlined in the current scb 2019 ib. 10. individuals who have had a malignancy (excluding nonmelanotic skin cancer) or lymphoproliferative disorder within the past 5 years from the date of first administration of the study vaccine/placebo (day 1). 11. individuals who have received any other investigational product within 30 days prior to day 1 or intent to participate in another clinical study at any time during the conduct of this study. 12. individuals with a body temperature ≥38.0 °c (≥100.4 °f) or any acute illness within 3 days of intended study vaccination. 13. individuals who have a previous confirmed or suspected illness caused by coronaviruses, sars-cov 1, sars-cov-2, and middle east respiratory syndrome (mers)-cov. 14. individuals who have received any prior vaccine against a coronavirus, including but not limited to sars-cov, sars-cov-2, mers-cov. 15. individuals who have received any other licensed vaccines within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to enrollment in this study or who are planning to receive any vaccine within 28 days (before or after) the study vaccine/placebos, with the exception of the seasonal influenza vaccine. 16. presence of uncontrolled chronic pulmonary, cardiovascular, renal, hepatic, neurologic, hematologic or metabolic (including diabetes mellitus) disorders, which would include the potential subject in a high-risk category for sars cov 2 infection and/or its complications. 17. individuals with known bleeding diathesis. 18. individuals with a body mass index <18.5 kg/m2 or >35.0 kg/m2. 19. individuals with a history of drug or alcohol abuse within the past 2 years. 20. individuals with a history of anaphylaxis or angioedema including but not limited to history of anaphylaxis after any vaccine. 21. individuals with any condition that, in the opinion of the investigator, would interfere with the primary study objectives or pose additional subject risk. 22. individuals who are research staff involved with the clinical study or family/household members of research staff.

1. individuals with any positive test for sars cov 2 infection, including but not limited to rt-pcr, at screening. 2. individuals with positive serology test results for sars cov 2 at screening. 3. individuals with behavioral or cognitive impairment in the opinion of the investigator. 4. individuals with any progressive or severe neurologic disorder, seizure disorder, or history of guillian-barré syndrome. 5. individuals who are not able to comprehend and to follow all required study procedures for the whole period of the study. 6. individuals with known or suspected impairment of the immune system, such as: 1. use of systemic (oral or parenteral) corticosteroids for ≥14 consecutive days within 60 days prior to day 1. use of inhaled, intranasal, or topical corticosteroids is allowed.note: systemic (oral or parenteral) corticosteroids are also prohibited for 3 weeks after the second dose of the study vaccine/placebo. 2. receipt of cancer chemotherapy within 5 years prior to day 1. 3. receipt of immunostimulants or immunosuppressants within 60 days prior to day 1. 4. known hiv or acquired immune deficiency syndrome (aids). 5. subjects with active or prior documented autoimmune disorder (such as potential immune-mediated diseases [pimds]). 6. receipt of parenteral immunoglobulin preparation, blood products, and/or plasma derivatives within 3 months prior to day 1 or planned during the full length of the study. 7. positive serology test results for hepatitis c virus antibody, hiv antibody, and/or hepatitis b virus surface antigen at screening. 8. individuals who are pregnant or breastfeeding. female subjects of childbearing potential must have a negative pregnancy test prior to administration of the study vaccine/placebo. 9. individuals who are allergic to any of the study vaccine/placebo components as outlined in the current scb 2019 ib. 10. individuals who have had a malignancy (excluding nonmelanotic skin cancer) or lymphoproliferative disorder within the past 5 years from the date of first administration of the study vaccine/placebo (day 1). 11. individuals who have received any other investigational product within 30 days prior to day 1 or intent to participate in another clinical study at any time during the conduct of this study. 12. individuals with a body temperature ≥38.0 °c (≥100.4 °f) or any acute illness within 3 days of intended study vaccination. 13. individuals who have a previous confirmed or suspected illness caused by coronaviruses, sars-cov 1, sars-cov-2, and middle east respiratory syndrome (mers)-cov. 14. individuals who have received any prior vaccine against a coronavirus, including but not limited to sars-cov, sars-cov-2, mers-cov. 15. individuals who have received any other licensed vaccines within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to enrollment in this study or who are planning to receive any vaccine within 28 days (before or after) the study vaccine/placebos, with the exception of the seasonal influenza vaccine. 16. presence of uncontrolled chronic pulmonary, cardiovascular, renal, hepatic, neurologic, hematologic or metabolic (including diabetes mellitus) disorders, which would include the potential subject in a high-risk category for sars cov 2 infection and/or its complications. 17. individuals with known bleeding diathesis. 18. individuals with a body mass index <18.5 kg/m2 or >35.0 kg/m2. 19. individuals with a history of drug or alcohol abuse within the past 2 years. 20. individuals with a history of anaphylaxis or angioedema including but not limited to history of anaphylaxis after any vaccine. 21. individuals with any condition that, in the opinion of the investigator, would interfere with the primary study objectives or pose additional subject risk. 22. individuals who are research staff involved with the clinical study or family/household members of research staff.