Created at Source Raw Value Validated value
Oct. 26, 2020, 8:29 a.m. oms

[{"arm_notes": "", "treatment_id": null, "treatment_name": "The subjects are randomly allocated to three mouth-rinse groups; namely povidone-iodine (PI); chlorhexidine gluconate (CHX) and cetylpyridinium chloride (CPC) and water control group. Allocation: using Robust Randomization App (RRApp) using block randomization technique Masking: single-blind Prior to saliva collection; patients are asked to refrain from eating; drinking; or performing oral hygiene procedures for at least 30 min. Three milliliters of saliva is collected by passive drool technique from all the enrolled COVID-19 patients at four timepoints. Firstly; a baseline saliva sample is collected prior to the intervention of the mouth-rinse. Immediately after this; patients are requested to rinse their mouth with the allocated mouth-rinse for 30 seconds. Commercial mouth-rinses are prepared at the dilution and dosage recommended by respective manufacturers. In brief; in the PI group 5 ml of PI mouthwash (commercially available as Betadine Gargle and Mouthwash 10 mg) diluted with 5 ml of water (0.5%) is used whereas in the CHX group; 15 mL of undiluted CHX mouthwash (commercially available as Pearly White Chlor-Rinse; 0.2% w/v) is used. In the CPC group and water control groups; 20 ml of 0.075% CPC (commercially available as Colgate Plax mouthwash) and 15 ml sterile water are used; respectively. Three milliliters of saliva is collected again from all subjects 5 minutes after the use of mouth-rinse. In order to evaluate the duration of the efficacy of mouth-rinses; salivary samples are collected at the 3 h and 6 h post-rinsing.", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]

[{"arm_notes": "", "treatment_id": 1015, "treatment_name": "Povidone-iodine", "treatment_type": "Mouthwash", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "", "treatment_id": 274, "treatment_name": "Chlorhexidine", "treatment_type": "Mouthwash", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "", "treatment_id": 268, "treatment_name": "Cetylpyridinium chloride", "treatment_type": "Mouthwash", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2187, "treatment_name": "Placebo", "treatment_type": "Placebo", "pharmacological_treatment": "Placebo"}]