Current inclusion criteria as of 25/11/2020: 1. Adults aged 18 to 55 years of age 2. Adults aged 56-69 years old (after review of safety data by DSMB in this age group in the UK trial) 3. Adults aged 70 and above years old (after review of safety data by DSMB in this age group in the UK trial) 4. Able and willing (in the Investigator’s opinion) to comply with all study requirements 5. Willing to allow the investigators to discuss the volunteer’s medical history with their General Practitioner/personal doctor and access all medical records when relevant to study procedures 4. For females of childbearing potential only, willingness to practice continuous effective contraception (see below) during the study and a negative pregnancy test on the day(s) of screening and vaccination 5. Agreement to refrain from blood donation during the course of the study 6. Provide written informed consent 7. Health professionals and/or adults at high risk of exposure to SARS-CoV-2 Previous inclusion criteria: 1. Adults aged 18 to 55 years of age. Upper age can be extended upon the availability of additional safety data in an older population 2. Able and willing (in the Investigator’s opinion) to comply with all study requirements 3. Willing to allow the investigators to discuss the volunteer’s medical history with their General Practitioner/personal doctor and access all medical records when relevant to study procedures 4. For females of childbearing potential only, willingness to practice continuous effective contraception (see below) during the study and a negative pregnancy test on the day(s) of screening and vaccination 5. Agreement to refrain from blood donation during the course of the study 6. Provide written informed consent

Current inclusion criteria as of 25/11/2020: 1. Adults aged 18 to 55 years of age 2. Adults aged 56-69 years old (after review of safety data by DSMB in this age group in the UK trial) 3. Adults aged 70 and above years old (after review of safety data by DSMB in this age group in the UK trial) 4. Able and willing (in the Investigator’s opinion) to comply with all study requirements 5. Willing to allow the investigators to discuss the volunteer’s medical history with their General Practitioner/personal doctor and access all medical records when relevant to study procedures 4. For females of childbearing potential only, willingness to practice continuous effective contraception (see below) during the study and a negative pregnancy test on the day(s) of screening and vaccination 5. Agreement to refrain from blood donation during the course of the study 6. Provide written informed consent 7. Health professionals and/or adults at high risk of exposure to SARS-CoV-2 Previous inclusion criteria: 1. Adults aged 18 to 55 years of age. Upper age can be extended upon the availability of additional safety data in an older population 2. Able and willing (in the Investigator’s opinion) to comply with all study requirements 3. Willing to allow the investigators to discuss the volunteer’s medical history with their General Practitioner/personal doctor and access all medical records when relevant to study procedures 4. For females of childbearing potential only, willingness to practice continuous effective contraception (see below) during the study and a negative pregnancy test on the day(s) of screening and vaccination 5. Agreement to refrain from blood donation during the course of the study 6. Provide written informed consent

1. Adults aged 18 to 55 years of age. Upper age can be extended upon the availability of additional safety data in an older population 2. Able and willing (in the Investigator’s opinion) to comply with all study requirements 3. Willing to allow the investigators to discuss the volunteer’s medical history with their General Practitioner/personal doctor and access all medical records when relevant to study procedures 4. For females of childbearing potential only, willingness to practice continuous effective contraception (see below) during the study and a negative pregnancy test on the day(s) of screening and vaccination 5. Agreement to refrain from blood donation during the course of the study 6. Provide written informed consent

1. Adults aged 18 to 55 years of age. Upper age can be extended upon the availability of additional safety data in an older population 2. Able and willing (in the Investigator’s opinion) to comply with all study requirements 3. Willing to allow the investigators to discuss the volunteer’s medical history with their General Practitioner/personal doctor and access all medical records when relevant to study procedures 4. For females of childbearing potential only, willingness to practice continuous effective contraception (see below) during the study and a negative pregnancy test on the day(s) of screening and vaccination 5. Agreement to refrain from blood donation during the course of the study 6. Provide written informed consent