1. Aged =18 years 2. Clinical, molecular (using IgM/IgG or RT-PCR), or lung imaging diagnosis of COVID-19 3. Deterioration of previously normal lung function defined as SaO2 of <90% in 0.5 FiO2, and/or a higher requirement of O2 than in the previous 24h 4. A score of 5 to 7 on the early warning scale for COVID-19 patients or a SOFA score between 2 and 10 5. Informed consent provided by patients or their representatives

1. Aged =18 years 2. Clinical, molecular (using IgM/IgG or RT-PCR), or lung imaging diagnosis of COVID-19 3. Deterioration of previously normal lung function defined as SaO2 of <90% in 0.5 FiO2, and/or a higher requirement of O2 than in the previous 24h 4. A score of 5 to 7 on the early warning scale for COVID-19 patients or a SOFA score between 2 and 10 5. Informed consent provided by patients or their representatives