Created at Source Raw Value Validated value
Oct. 26, 2020, 8:29 a.m. oms

[{"arm_notes": "", "treatment_id": null, "treatment_name": "Intervention: Adalimumab Regimen 1. A loading dose of 80 mg Adalimumab given as two injections of 40 mg at separate sites in the thigh or abdomen. Subjects with persistent symptoms and signs may receive a second dose of Adalimumab 40 mg after 14 days. Regimen 2. A loading dose of 160 mg Adalimumab given as four injections of 40 mg at separate sites in the thigh or abdomen. Subjects with persistent symptoms and signs may receive a second dose of Adalimumab 80 mg after 14 days. This is in addition to standard care as per local Hospital at Home network treatment pathways. Note: The second regimen will start recruitment following a preliminary assessment of safety of the first regimen (25 subjects randomised to regimen 1). Comparator: Standard care as per local treatment pathways for those with confirmed COVID-19 being managed in the community. Participants will be followed up for up to 120 days. Eligible patients will be randomised using the centralised validated computer randomisation program through a secure (encrypted) web-based service; RRAMP (https://rramp.octru.ox.ac.uk); provided by the Oxford Clinical Trials Research Unit (OCTRU); accessed via the study\u2019s RedCap instance; with a minimisation algorithm to ensure balanced allocation across treatment groups; (incorporating a non-deterministic random element) to include age; gender and presence of metabolic or cardiovascular co-morbidities in a 1:1 ratio to either Adalimumab (2 regimens) with standard usual care or standard usual care. Within the Adalimumab arm; following the review of the initial 25 patients who will receive regimen one; patients within Adalimumab will be randomly a", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]

[{"arm_notes": "", "treatment_id": 27, "treatment_name": "Adalimumab", "treatment_type": "Other targeted therapies", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2188, "treatment_name": "Standard of care", "treatment_type": "Standard of care", "pharmacological_treatment": "Standard of care"}]