1. Aged =18 years 2. Admitted to ICU and intubated 3. Serious COVID-19 as per World Health Organization and Saudi Centers for Disease Control and Prevention case definition. SARS-CoV-2 infection should be confirmed by real-time polymerase chain reaction (RT-PCR) assays 4. At risk of cytokine release syndrome (CRS)

1. Aged =18 years 2. Admitted to ICU and intubated 3. Serious COVID-19 as per World Health Organization and Saudi Centers for Disease Control and Prevention case definition. SARS-CoV-2 infection should be confirmed by real-time polymerase chain reaction (RT-PCR) assays 4. At risk of cytokine release syndrome (CRS)