1. Healthy adults from the following age ranges: 1.1. For the dose escalation and evaluation, aged 18- 45 years on the day of screening 1.2. For the expanded safety evaluation, aged 18-75 years on the day of screening 2. At a similar risk of acquiring SARS-CoV2 infection to the general population 3. Willing and able to provide written informed consent 4. If female and of childbearing potential and not sterilised, willing to use a highly effective method of contraception from screening until 18 weeks after the last injection 5. If male and not sterilised, willing to avoid impregnating female partners from screening until 18 weeks after last injection 6. Willing to avoid all other vaccines 4 weeks after the first injection through to 4 weeks after the second injection 7. Willing and able to comply with visit schedule, complete online diaries and provide samples 8. Willing to grant authorised persons access to his/her trial-related medical record and GP records either directly or indirectly

1. Healthy adults from the following age ranges: 1.1. For the dose escalation and evaluation, aged 18- 45 years on the day of screening 1.2. For the expanded safety evaluation, aged 18-75 years on the day of screening 2. At a similar risk of acquiring SARS-CoV2 infection to the general population 3. Willing and able to provide written informed consent 4. If female and of childbearing potential and not sterilised, willing to use a highly effective method of contraception from screening until 18 weeks after the last injection 5. If male and not sterilised, willing to avoid impregnating female partners from screening until 18 weeks after last injection 6. Willing to avoid all other vaccines 4 weeks after the first injection through to 4 weeks after the second injection 7. Willing and able to comply with visit schedule, complete online diaries and provide samples 8. Willing to grant authorised persons access to his/her trial-related medical record and GP records either directly or indirectly