- intolerance to RAS-I and ARB - Contraindications against ACE/ARB according to current clinical standard - History of falls (more than 2 falls in the last 8 weeks) - Symptomatic hypotension (i.e. blood pressure < 100 mmHg systolic and/or 50 mmHg diastolic together with hypotensive symptoms) - Acute renal failure from stage 2 - pregnancy

- intolerance to RAS-I and ARB - Contraindications against ACE/ARB according to current clinical standard - History of falls (more than 2 falls in the last 8 weeks) - Symptomatic hypotension (i.e. blood pressure < 100 mmHg systolic and/or 50 mmHg diastolic together with hypotensive symptoms) - Acute renal failure from stage 2 - pregnancy