inclusion criteria: 1. male or female, aged ≥ 18 years 2. present a confirmed or pending diagnosis of covid-19, but with tomographic and clinical signs strongly suggestive of sars-cov-2 infection (covid-19), with pulmonary impairment greater than or equal to 50% and: i. oxygen saturation \<95%; ii. curb-65 rating ≥ a 4; d) participants with a score on who ordinal scale that measures illness severity over time equal to 5 (hospitalized with non-invasive ventilation or high-flow oxygen).

inclusion criteria: 1. male or female, aged ≥ 18 years 2. present a confirmed or pending diagnosis of covid-19, but with tomographic and clinical signs strongly suggestive of sars-cov-2 infection (covid-19), with pulmonary impairment greater than or equal to 50% and: i. oxygen saturation \<95%; ii. curb-65 rating ≥ a 4; d) participants with a score on who ordinal scale that measures illness severity over time equal to 5 (hospitalized with non-invasive ventilation or high-flow oxygen).

inclusion criteria: 1. male or female, aged ≥ 18 years 2. present a confirmed or pending diagnosis of covid-19, but with tomographic and clinical signs strongly suggestive of sars-cov-2 infection (covid-19), with pulmonary impairment greater than or equal to 50% and: i. oxygen saturation <95%; ii. curb-65 rating ≥ a 4; d) participants with a score on who ordinal scale that measures illness severity over time equal to 5 (hospitalized with non-invasive ventilation or high-flow oxygen).

inclusion criteria: 1. male or female, aged ≥ 18 years 2. present a confirmed or pending diagnosis of covid-19, but with tomographic and clinical signs strongly suggestive of sars-cov-2 infection (covid-19), with pulmonary impairment greater than or equal to 50% and: i. oxygen saturation <95%; ii. curb-65 rating ≥ a 4; d) participants with a score on who ordinal scale that measures illness severity over time equal to 5 (hospitalized with non-invasive ventilation or high-flow oxygen).