COVID-19 trials registries data warehouse

The purpose of this data warehouse is to provide the COVID-NMA Initiative with near real time identification of all COVID-19 related trials.

The data is being used by the COVID-NMA Initiative to develop the living mapping and data visualizations of treatments and vaccines for COVID-19, worldwide.

Every week they screen the four under mentioned registries to identify and extract data from RCTs evaluating the effectiveness of interventions for preventing and treating COVID-19 as well as of all trials assessing vaccines.

Their work is relying on two main steps:

1. Automatic data extraction (using the data warehouse)
2. Annotation of newly extracted data (outside the data warehouse)

The data warehouse is fully functional for step 1 and is under development to integrate step 2 within its interface in a near future.

1. Automatic data extraction

Search strategy

Trials are collected from four trial registries sources:

• International Clinical Trials Registry Platform (ICTRP) (daily) : the platform is managed by WHO and gathers trials from 17 primary registries across the world (see full list on the ICTRP website).
• ClinicalTrials.gov (daily)
• EU Clinical Trials Register (daily)
• Iranian Registry of Clinical Trials (IRCT) (daily)

Data collection

Trial characteristics data is automatically collected from registries and then available to download for the COVID-NMA team trials mapping team.

Full details on data characteristics are provided on the codebook.

2. Data annotation (under development)

Once collected and download, any missing or incomplete information is double checked manually by annotator to fill any gap. This work is coordinated outside of the data warehouse by the COVID-NMA trials mapping team. This step will be soon available directly into the data warehouse, allowing to modify data before to download them.